Effect of Crystalloids With Different SID on pH, and Urinary Electrolytes During General Anesthesia

Summary

The present study will investigate variations in acid base equilibrium caused by the administration of four different crystalloids with increasing strong ion difference (0.9% saline, Ringer's lactate, Ringer's acetate, plasmalyte-like solution) in patients during general anesthesia.

The same crystalloid will be administered throughout the surgery. In order to assess the effect of hemodilution, every patient will receive two fluid boli with different volumes of the same solution. pH and strong ion variations, togher with the renal response to acid base disturbances, will be analysed.

Conditions

• SID
• Acid-Base Imbalance

Interventions

OTHER

0.9% saline administration

Each patient will receive 0.9%saline based on attending physician decision

OTHER

Ringer's lactate administration

Each patient will receive Ringer's lactate based on attending physician decision

OTHER

Plasmalyte-like solution administration

Each patient will receive Plasmalyte-like solution based on attending physician decision

Sponsors & Collaborators

• Cristina Dominedò

  collaborator UNKNOWN

• Marco Rossi

  collaborator UNKNOWN

• Rossano Festa

  collaborator UNKNOWN

• Nicoletta Filetici

  collaborator UNKNOWN

• Marta Cicetti

  collaborator UNKNOWN

• Domenico Luca Grieco

  collaborator UNKNOWN

• Massimo Antonelli

  collaborator UNKNOWN

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS

  lead OTHER

Principal Investigators

• Antonio M Dell'Anna, MD · Fondazione Policlinico A. Gemelli

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-12-10

Primary Completion

2022-06-30

Completion

2023-07-30

Countries

• Italy

Study Locations