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Non Carbonic Buffer Power of Critical Ill Patients With Sepsis

NCT03503214 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2019-04-25

No results posted yet for this study

Summary

Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.

The human organism is protected against acid-base disorders by several compensatory mechanisms that minimize pH variations in case of blood variations in carbon dioxide content. The aim of the present study is to quantify the buffer power, i.e. the capacity to limit pH variations in response to carbon dioxide changes, in critically ill septic patients and compare these results with data collected from healthy volunteers.

Conditions

  • Acid-Base Imbalance
  • Respiratory Acidosis
  • Respiratory Alkalosis

Interventions

DIAGNOSTIC_TEST

In vitro determination of non-carbonic buffer power

In vitro measurement of the non-carbonic buffer power by the means of equilibration of whole blood and isolated plasma with gas mixtures containing different concentrations of carbon dioxide

DIAGNOSTIC_TEST

Classic description of acid-base status

Measurement of plasma electrolytes, hemoglobin concentration, albumin and phosphates to compute acid-base variables according to Stewart's approach.

Sponsors & Collaborators

  • Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

    lead OTHER

Principal Investigators

  • Thomas Langer, MD · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano

  • Antonio Pesenti, MD · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano

  • Giacomo Grasselli, MD · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-03-07
Primary Completion
2019-02-20
Completion
2019-02-20

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03503214 on ClinicalTrials.gov