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Prediction of WMH in Migraine Using a BOLD-CVR Map

NCT03494673 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 74

Last updated 2019-04-10

No results posted yet for this study

Summary

Brain white matter hyperintensities (WMHs) are prevalent in migraineurs, of which the mechanism is still unclear. The investigators aimed to test the spatial association between areas with reduced cerebrovascular reactivity (CVR) to hypercapnic stimuli and consequent development of WMHs.

Conditions

Interventions

DIAGNOSTIC_TEST

BOLD MRI

1. Prospective End-tidal targeting RespirAct device(A specially designed gas blender and sequential rebreathing circuit) will be used to implement the gas targeting method which involves precise elevations in End-tidal PCO2 while maintaining a fixed End-tidal PO2 2. BOLD MR images will be obtained by using a T2\*-weighted two-dimensional gradient-echo sequence with echoplanar readout.

Sponsors & Collaborators

Principal Investigators

  • Mi Ji Lee, MD · Samsung Medical Center, Sungkyunkwan University School of Medicine

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-07-13
Primary Completion
2020-02-28
Completion
2020-02-28

Countries

  • South Korea

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03494673 on ClinicalTrials.gov