MedTrace Logo

MRI of Lung Structure and Function in Preterm Children

NCT03475264 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2025-08-01

No results posted yet for this study

Summary

The MRI tools developed by the investigators are well positioned for assessing regional changes in lung structure and function in preterm children with bronchopulmonary dysplasia (BPD), in which airway limitation similar to asthma, alveolar simplification similar to emphysema and pulmonary vascular stunting are expected. To the investigator's knowledge, the combination of ultra short echo time (UTE) proton, pulmonary vascular proton and hyperpolarized 129Xe MRI have not yet been explored in BPD, either clinically or preclinically. The investigators propose that a comprehensive MRI examination may be useful from a diagnostic perspective, MRI of preterm children without BPD may reveal changes which are otherwise clinically 'silent' yet still place children at risk for future chronic lung disease in later life.

Conditions

  • Bronchopulmonary Dysplasia

Interventions

DIAGNOSTIC_TEST

Lung MRI

Participants will be undergoing hyperpolarized xenon and proton lung MRI

Sponsors & Collaborators

  • The Hospital for Sick Children

    lead OTHER

Eligibility

Min Age
6 Years
Max Age
9 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-01
Primary Completion
2019-10-08
Completion
2019-10-08

Countries

  • Canada

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03475264 on ClinicalTrials.gov