MedTrace Logo

Low-field Magnetic Resonance Imaging in Pediatric Post Covid-19

NCT05445531 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 111

Last updated 2022-07-06

No results posted yet for this study

Summary

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) is a new coronavirus and identified causative agent of COVID-19 disease. These viruses predominantly cause mild colds, but can sometimes cause severe pneumonia and pulmonary skeletal changes. By low-field gastric magnetic resonance imaging (NF-MRI), only a small number of structural, scarring changes were seen in a preliminary study of pediatric and adolescent patients with past SARS-CoV-2 infection. In contrast, however, extensive changes in ventilation and blood flow function of the lungs were seen.

The long-term consequences and spontaneous progression of these changes on imaging are completely unclear. The aim of this study is to assess the course of these functional lung changes in pediatric and adolescent patients and to validate them with other standard clinical procedures.

Conditions

Interventions

DIAGNOSTIC_TEST

Low-field magnetic resonance imaging

Functional and morphologic imaging of the lungs

DIAGNOSTIC_TEST

Nailfold capillaroscopy

Imaging of nailfold microvasculature

DIAGNOSTIC_TEST

Spiroergometry

Cardiopulmonary exercise testing

DIAGNOSTIC_TEST

Realtime deformability cytometry

High-throughput measurement of cell deformability and physical properties

Sponsors & Collaborators

  • University of Erlangen-Nürnberg Medical School

    lead OTHER

Principal Investigators

  • Ferdinand Knieling, MD · University Hospital Erlangen

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
5 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-08
Primary Completion
2023-01-31
Completion
2023-03-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05445531 on ClinicalTrials.gov