MAST Trial: Multi-modal Analgesic Strategies in Trauma

Summary

This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared \[original multimodal pain regimen (MMPR) compared to multi-modal analgesic strategies for trauma (MAST) MMPR\].

Conditions

• Nonspecific Pain Post Traumatic Injury

Interventions

DRUG

Acetaminophen IV/PO

Acetaminophen 1g IV/PO every 6 hours

DRUG

Acetaminophen PO

Acetaminophen 1g PO every 6 hours

DRUG

Ketorolac

Ketorolac 30mg IV once

DRUG

Celebrex

Celebrex 200mg PO every 12 hours

DRUG

Naproxen

Naproxen 500mg PO every 12 hours

DRUG

Tramadol

Tramadol 100mg PO every 6 hours

DRUG

Pregabalin

Pregabalin 100mg PO every 8 hours

DRUG

Gabapentin

Gabapentin 300mg PO every 8 hours

DRUG

Lidocaine

Lidocaine patch every 12 hours

DRUG

Opioids

Opioid options include: Oral Opioids (Codeine, Tramadol, Hydrocodone, Oxycodone, Methadone, Morphine, Hydromorphone); Transdermal Opioid (Fentanyl); Intravenous Opioids (Morphine, Hydromorphone, Fentanyl)

DRUG

Regional anesthesia

Regional anesthesia

Sponsors & Collaborators

• National Center for Advancing Translational Sciences (NCATS)

  collaborator NIH

• The University of Texas Health Science Center, Houston

  lead OTHER

Principal Investigators

• John Harvin, MD · The University of Texas Health Science Center, Houston

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

16 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-04-02

Primary Completion

2019-07-03

Completion

2019-07-03

FDA Drug

Yes

Countries

• United States

Study Locations