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Exploration of the Enteric Nervous System in Alzheimer Disease

NCT03472183 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2020-04-01

No results posted yet for this study

Summary

The close homology between the central and enteric nervous system suggests that a disease process affecting the central nervous system could also involve its enteric counterpart. This has already been demonstrated for patients with Parkinson's disease but needs to be proven for Alzheimer's disease. Studies on enteric nervous system during Alzheimer's disease are indeed in low number and don't have led to definite conclusion. The investigators thus propose to realize a complete analysis of the enteric nervous systems in Alzheimer's disease by studying the presence of "tau' protein, of beta-amyloid peptide,...

not only by immunohistochemical but also by a biochemical approach. This study will be realized from colonic samples.

Conditions

  • Alzheimer Disease

Interventions

OTHER

biopsies of colon

Removal of additional biopsies of colon during the course of a colonoscopy planned for usual medical follow-up of patient

Sponsors & Collaborators

  • Nantes University Hospital

    lead OTHER

Principal Investigators

  • Pascal DERKINDEREN, Pr · Nantes University Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-04-26
Primary Completion
2019-09-18
Completion
2019-09-18

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03472183 on ClinicalTrials.gov