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The Effect of Macronutrients on Satiety and Gut Hormone Responses

NCT03466047 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2020-10-20

Study results available
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Summary

This study is part of a research theme aiming at elucidating the physiological mechanisms of action of weight loss after gastric bypass surgery. The Roux-en-Y Gastric Bypass procedure induces pronounced and sustained weight loss, but the physiological mechanisms of action are not completely clear. Neither mechanical restriction of food intake nor malabsorption, are the main contributing factors. The enhanced postprandial responses of gut hormones (e.g. GLP-1 and PYY) which increase satiety as well as energy expenditure after surgery suggest a changed physiological set point for appetite and metabolism.

Our hypothesis is that the intake of high quantity of protein in a microcapsule form would be able to reach the distal parts of the intestinal mucosa and stimulate maximum stimulation of the anorectic gut hormones. The higher functions of the brain will respond to these strong neuroendocrine signals by ensuing satiety and fullness.

Conditions

  • Eating Behavior

Interventions

DIETARY_SUPPLEMENT

Protein stomach

encapsulated protein stomach

DIETARY_SUPPLEMENT

Protein distal small intestine

encapsulated protein distal small intestine

DIETARY_SUPPLEMENT

CHO stomach

encapsulated CHO stomach

DIETARY_SUPPLEMENT

CHO distal small intestine

encapsulated CHO distal small intestine

DIETARY_SUPPLEMENT

Fat stomach

encapsulated Fat stomach

DIETARY_SUPPLEMENT

Fat distal small intestine

encapsulated Fat distal small intestine

Sponsors & Collaborators

  • Imperial College London

    lead OTHER

Principal Investigators

  • Carel le Roux · Imperial College London

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-03-15
Primary Completion
2019-01-01
Completion
2019-01-01

Countries

  • Ireland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03466047 on ClinicalTrials.gov