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Influence of Mechanical Bowel Preparation on GI Microbiota

NCT03465293 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 15

Last updated 2018-03-14

No results posted yet for this study

Summary

The mechanical bowel preparation (BP) used to clean the colon prior to colonoscopy frequently results in a significant but temporary reduction in patient's symptoms for a number of bowel disorders including symptomatic uncomplicated diverticular disease. The cause of this improvement is unknown.

We hypothesise that changes to the gut microbial population (microbiota) are responsible for this improvement and that the repopulation of the GI tract with bacteria following colonoscopy results in a return of their normal symptoms. This pilot study will test this in a preliminary way by examining the stool, urine and blood of patients before and after bowel preparation to detect any destabilising effect that BP has on the gut microbiota and to what extent the microbiota repopulates at 3 months If the hypothesis is proven, this study will show that BP generates a 'window of opportunity' in which to influence the subsequent re-establishment of the microbiota. This is with the eventual aim of correcting potential dysbiosis and preventing the progression of symptomatic uncomplicated diverticular disease (SUDD).

Conditions

  • Diverticulosis, Colonic
  • Microbiota

Interventions

OTHER

Bacterial composition and activity after bowel preparation

Bacterial composition and activity and patient's symptoms will be assessed pre and post bowel preparation taken as part of the preparation to have a pre-planned colonoscopy

Sponsors & Collaborators

  • Royal Berkshire Hospital

    collaborator UNKNOWN

  • University of Reading

    lead OTHER

Principal Investigators

  • Marie Lewis, PhD · Reading University

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-05-01
Primary Completion
2018-10-01
Completion
2019-04-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03465293 on ClinicalTrials.gov