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The Relationship Between Arterial Stiffness and Respiratory Failure in Motor Neurone Disease

NCT03444428 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 13

Last updated 2021-10-01

No results posted yet for this study

Summary

* Patients with Motor Neurone Disease (MND) admitted to Lane Fox Unit /Royal Brompton Hospital and/or reviewed in Lane Fox Unit /Royal Brompton Hospital clinics and/or outreach review will be approached for participation in the study
* Physiological assessment and measurement of arterial stiffness will be performed in all patients at baseline and after the use of non invasive ventilation for 6 weeks.
* MND patients not requiring mechanical ventilation will serve as controls since non invasive ventilation cannot be withheld from MND patients in type II respiratory failure.
* Data will be analysed to look for differences between groups, relationships in baseline or change from baseline in respiratory physiological measures, inflammatory indices, breathlessness, and arterial stiffness.

* Age, Height, Weight
* History and Physical Examination
* Evaluation of dysponea: mMRC, Borg Scale (Seated-Supine)
* Amyotrophic lateral sclerosis functional rating scale (ALSFRS-R)
* Sleep Disordered Breathing in Neuromuscular Disease Questionnaire (SiNQ-5)
* 24 hour blood pressure monitor
* Carotid-femoral pulse wave velocity
* Respiratory Muscle Strength - Maximal Inspiratory Pressure, Maximal Expiratory Pressure, and Sniff Nasal Inspiratory Pressure
* Spirometry - FEV1 and FVC
* Arterial Blood Gas
* CRP and fibrinogen (clinically)
* Breathe CO exhale

Conditions

  • Motor Neurone Disease
  • Hypoxemia and/or Hypercapnia

Interventions

OTHER

Non Invasive Ventilation

Assessments for those participants who are being set up onto NIV

OTHER

Without Non Invasive Ventilation

Assessments for those participants who are not being set up onto NIV

Sponsors & Collaborators

  • Guy's and St Thomas' NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Patrick Murphy · Guys and St Thomas NHS Foundation Trust

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-21
Primary Completion
2021-06-30
Completion
2021-06-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03444428 on ClinicalTrials.gov