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Olfactory Function and Delayed Neurocognitive Recovery

NCT03441074 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 131

Last updated 2025-07-31

No results posted yet for this study

Summary

To explore whether odor enrichment can reduce the risk of delayed neurocognitive recovery as an intervention strategy.

Conditions

  • Delayed Neurocognitive Recovery

Interventions

BEHAVIORAL

Odor Enrichment

Patients in intervention group will get odor enrichment during perioperative period (3 days before the surgery and 7 days after the surgery). Odor-enriched participants were exposed daily for 24 hours to different aromatic fragrances (phenyl ethyl alcohol - rose; eucalyptol - eucalyptus; citronellal - lemon; eugenol - cloves) referred to previous studies. Odors were changed for each subject after 24 hours. According to previous studies, 10 drops of the 100% essential oil (0.5 ml) were dropped on a fabric which was placed in tea bags hanging at the hospital bedside.

Sponsors & Collaborators

  • Massachusetts General Hospital

    collaborator OTHER

  • Shanghai 10th People's Hospital

    lead OTHER

Principal Investigators

  • Yuan Shen · Shanghai 10th People's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2021-12-31
Completion
2022-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03441074 on ClinicalTrials.gov