Pulmonary Surfactant(PS) Therapy at High Altitude Area

Summary

The traditional concept believes that the etiology of neonatal respiratory distress syndrome (RDS) is immature development of lung,especially the surfactant synthesis system,and RDS is still one of the major causes of mortality and morbidity in newborns, especially premature infants\[1\].In recent years, using pulmonary surfactant replacement therapy (PS treatment) in the treatment of respiratory distress syndrome (RDS) is a major breakthrough in neonatal medicine \[2\].Combined with clinical practice and experience,and through Meta analysis of related randomized controlled trials (RCTs),it confirms that natural surfactant treatment can reduce mortality,the incidence of pulmonary air leaks (pneumothorax and interstitial lung emphysema),and the incidence of bronchopulmonary dysplasia (BPD) or 28-day-old mortality.For RDS in preterm infants whose gestation is \<35 weeks ,surfactant replacement therapy is also more effective than in nearly term and full term infants.Therefore, in the analysis of cases of different gestational age groups,the investigators should focus on the study of premature infants cases.Due to less relevant research for using PS treatment to cure newborn RDS in high altitude area,this retrospective study conducts statistics and analysis of recently three-year cases in some hospital of high altitude area,to explore the treatment effect of the high altitude region and the impact of altitude on the treatment.

Conditions

• NRDS
• Surfactant

Interventions

DRUG

surfactant

Pulmonary surfactant was administrated if the baby was diagnosed with respiratory distress syndrome

Sponsors & Collaborators

• the first people hospital of Tibet autonomous region

  collaborator UNKNOWN

• the second people hospital of Lasa

  collaborator UNKNOWN

• the first people hospital of Shigatse

  collaborator UNKNOWN

• the first people hospital of Lasa

  collaborator UNKNOWN

• the people hospital of Linzhi

  collaborator UNKNOWN

• the people hospital of Laqu

  collaborator UNKNOWN

• Shannan People's Hospital

  collaborator OTHER

• the people hospital of Changdu

  collaborator UNKNOWN

• the people hospital of Ali

  collaborator UNKNOWN

• the second people hospital of Tibet autonomous region

  collaborator UNKNOWN

• Women and Children Hospital of Qinghai Province

  collaborator OTHER

• Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

  lead OTHER

Eligibility

Min Age

1 Minute

Max Age

12 Hours

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-01-01

Primary Completion

2017-12-31

Completion

2017-12-31