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Study of Platelets Sialylation by Flow Cytometry for the Differential Diagnosis of ICT

NCT03421392 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2022-02-01

No results posted yet for this study

Summary

Idiopathic thrombocytopenic purpura (ITP) is the most frequent auto-immune cytopenia. There is no specific biological marker and the diagnosis often results from the exclusion of other differential diagnoses, notably inherited thrombocytopenia.

Recent studies have reported an original platelet destruction mechanism in ITP, by antibody-mediated desialylation of membrane proteins. The detection of platelet sialylation can be readily achieved using flow cytometry. This could provide a new biomarker of ITP, useful to ascertain a diagnosis of ITP and guide towards proper patient management.

Conditions

  • Idiopathic Thrombocytopenic Purpura

Interventions

OTHER

non interventional study

non interventional study

Sponsors & Collaborators

  • Nantes University Hospital

    lead OTHER

Principal Investigators

  • Marc Fouassier, Dr · Nantes University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2019-10-23
Completion
2020-11-01

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03421392 on ClinicalTrials.gov