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The Association Between Platelet Reactivity and Bleeding Risk in Adult ITP

NCT03377439 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2017-12-19

No results posted yet for this study

Summary

It seems reasonable to assume that patients who present significant bleeding symptoms may have different quality of platelets than those without bleeding. This question was addressed in a study that examined platelet function in adult ITP patients, which try to determine whether this correlated with bleeding risk. Previous reports have suggested that measuring platelet function may help define patients at highest risk of bleeding. In addition, Middelburg and colleagues corrected platelet function for quartile of platelet count, using \<32×10\^9/L as the lowest cohort and \>132×10\^9/L as the top quartile. They demonstrated that increased platelet reactivity (as measured by flow cytometry) was associated with decreased risk of bleeding but particularly for those patients with the lowest platelet counts. Further studies in a larger cohort are needed to confirm this correlation. Our study aimed at standardizing a prediction model to evaluate the bleeding risk of adult ITP patients with the use of platelet function tests.

Conditions

Interventions

OTHER

Platelet function tests

Platelet reactivity was measured by flow cytometry, filopodia detection and the platelet aggregation analyzer.

Sponsors & Collaborators

  • Traditional Chinese Medicine Hospital Affiliated to Shandong University

    collaborator UNKNOWN

  • Jinan Central Hospital

    collaborator OTHER

  • Qianfoshan Hospital

    collaborator OTHER

  • Shandong Provincial Hospital

    collaborator OTHER_GOV

  • Shandong University Second Hospital

    collaborator UNKNOWN

  • Shandong University

    lead OTHER

Principal Investigators

  • Jun Peng, MD, PhD · Qilu Hospital, Shandong University

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-12-01
Primary Completion
2018-12-31
Completion
2018-12-31

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03377439 on ClinicalTrials.gov