MedTrace Logo

Vitamin D as a Factor Modifying Adaptation to Exercise

NCT03417700 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2021-05-11

No results posted yet for this study

Summary

Physical activity is a recommended, indispensable element of a healthy lifestyle as well as a countermeasure against many diseases often accompanied by the acute or chronic low grade inflammation. Papers published in recent years have demonstrated the anti-inflammatory effect of exercise. Based on current knowledge of the topic, own experience and preliminary work, it is expected the proposed research to provide information on the mechanism either determining or limiting pro-healthy effects of exercise in different age groups of people. Three different training programmes will be investigated. Specific goals of the project include the following:

1. Establish, whether regular Nordic Walking training and HIIT can reduce the low-grade systemic inflammation and which type of training is the most effective at doing so.
2. Establish, whether regular training can prevent muscle sarcopenia and assess if those changes are related to the concentration of the autophagy-inducing stress protein, HMGB1.
3. Establish, whether regular Nordic Walking training alters iron metabolism and evaluate its correlation with the inflammatory markers and bone-morphogenesis.
4. Establish, whether muscle-released irisin signals growth in the BDNF concentration in response to exercise and if these changes improve cognitive function.
5. Establish, whether Nordic Walking or HIIT training effectively improve the blood lipid profile and aerobic capacity, and if these effects correlate with the blood 25-OHD concentration.
6. Establish, whether concentration of vitamin D alters adaptation to training and modifies immunological response to regular training process.

Conditions

  • Vitamin D3 Deficiency

Interventions

DIETARY_SUPPLEMENT

NW training

NW training

DIETARY_SUPPLEMENT

Placebo

training with placebo

DIETARY_SUPPLEMENT

HICT

Training and vitamin D

Sponsors & Collaborators

  • Gdansk University of Physical Education and Sport

    lead OTHER

Principal Investigators

  • Ewa Ziemann · Gdansk University of Physical Education and Sport, Poland

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
15 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-05
Primary Completion
2020-01-01
Completion
2020-01-10

Countries

  • Poland

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03417700 on ClinicalTrials.gov