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Personalization of AntiTB Treatment: Evaluation of Pharmacological Determinants of Treatment Response

NCT03416309 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 257

Last updated 2019-04-17

No results posted yet for this study

Summary

The aim of the study is to investigate the possible correlation of plasma drug concentrations with Time To Positivity (TTP) in liquid culture in patients with active pulmonary multi sensitive TB in the first two weeks of treatment. Secondary aims are: the correlation between plasma drug concentrations and hepato/neuro toxicity; the impact of different allelic variants on PK data, toxicity and TTP in liquid culture; the feasibility of using dried blood/plasma spots to measure plasma concentrations of anti-TB drugs and determine genetic polymorphisms.

Conditions

  • Tuberculosis, Pulmonary

Sponsors & Collaborators

  • Research Center Borstel

    collaborator OTHER

  • University of Turin, Italy

    lead OTHER

Principal Investigators

  • Ilaria Motta, MD · University of Turin, Italy

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-25
Primary Completion
2021-02-28
Completion
2022-02-28

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03416309 on ClinicalTrials.gov