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Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients

NCT03410771 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 68

Last updated 2018-01-30

No results posted yet for this study

Summary

Bioelectrical impedance analysis is studied as a bedside tool to estimate capillary leak in order to guide dosing of hydrophilic antimicrobials.

Conditions

  • Electric Impedance
  • Pharmacokinetics
  • Capillary Leak Syndrome

Interventions

DRUG

Monitor antibiotic exposure (PK profile)

several plasma samples to measure drug exposure

DEVICE

Bioelectrical impedance analysis to measure body composition

non invasive analysis (electrodes) to measure extra- and intracellular, and total body water.

Sponsors & Collaborators

  • KU Leuven

    collaborator OTHER

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Principal Investigators

  • Isabel Spriet, PharmD PhD · Universitaire Ziekenhuizen KU Leuven

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-01
Primary Completion
2016-03-31
Completion
2016-06-01

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03410771 on ClinicalTrials.gov