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Donation of Post Mortem Tumor Tissues

NCT03385980 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2023-03-22

No results posted yet for this study

Summary

DONUM is an observational prospective independent protocol for patients with advanced lung cancer, colorectal cancer or cancer of unknown primary, willing to donate their tumor tissue samples post mortem for biomedical research purposes. All patients who fulfill the inclusion criteria will be eligible for the study after giving their Informed consent. Informed Consent will be obtained in two steps. During the pre-information step patients will be acquainted with the existence of a post-mortem cancer tissue donation research program governed by the DONUM protocol. If the patients manifest interest to participate into the program (in writing) during the pre-information step, they will proceed to step 2 and undergo the final informed consent process.

Conditions

  • NSCLC Stage IV
  • CRC
  • CUP

Interventions

OTHER

Proteomic analysis

Proteomic analysis of tissues collected from all sites of disease, guided by either imaging performed prior to the patient's death or post-mortem findings. Peripheral blood mononuclear cells (PBMC) will be collected with the purpose of identifying somatic changes occurring specifically in the tumor cells and not in normal DNA of the same patient.

Sponsors & Collaborators

  • University of Turin, Italy

    collaborator OTHER

  • Fondazione del Piemonte per l'Oncologia

    collaborator OTHER

  • Niguarda Hospital

    lead OTHER

Principal Investigators

  • Salvatore Siena, MD · Niguarda Cancer Center

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-02-11
Primary Completion
2021-12-30
Completion
2022-04-30

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03385980 on ClinicalTrials.gov