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Resection of the Esophagus and Subsequent Weight Loss

NCT03377660 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2024-03-27

No results posted yet for this study

Summary

The investigators aim to ascertain how food reward signals and eating behaviour relates to the gut-brain pathway in weight-losing patients after curative surgery for oesophageal cancer, and how this pathway responds to clinical treatment for this unintentional weight loss. The primary outcomes are the blood oxygen level dependent (BOLD) signal on functional MRI (fMRI), and the breakpoint during the progressive ratio task (PRT - a measure of eating behaviour), how these differ in response to multiple clinical treatment options, as well as how they relate to weight gain while on treatment.

Conditions

  • Esophageal Cancer
  • Weight Gain
  • Eating Behavior
  • Food Reward

Interventions

OTHER

Clinical treatment

Patients undergo clinical treatment as indicated, they are studied before and after.

Sponsors & Collaborators

  • University College Dublin

    collaborator OTHER

  • St. James's Hospital, Ireland

    collaborator OTHER

  • Imperial College London

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2023-03-01
Completion
2023-06-01

Countries

  • Ireland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03377660 on ClinicalTrials.gov