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Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm

NCT03371602 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2023-07-07

No results posted yet for this study

Summary

The aim of this study is to study the combined impact of mechanical ventilation and sepsis on the human diaphragm in order to establish the neutral, protective or destructive character of mechanical ventilation by studying the diameter of the fibers, activation of proteolytic systems, inhibition of protein synthesis, tissue inflammation as well as contractile function.

Conditions

  • Respiration, Artificial

Interventions

PROCEDURE

surgery

a diaphragmatic biopsy (100 microgram) and a parietal biopsy will be performed by the surgeon during surgery.

PROCEDURE

multi-organ sampling

a diaphragmatic biopsy (100 microgram) will be performed by the surgeon during surgery.

Sponsors & Collaborators

  • Hospices Civils de Lyon

    lead OTHER

Principal Investigators

  • Céline Guichon · Hospices Civils de Lyon

Study Design

Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-06-16
Primary Completion
2021-07-17
Completion
2021-07-17

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03371602 on ClinicalTrials.gov