Metabolic Signature of Healthy Lifestyle and HCC

Summary

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and its incidence is increasing including in regions where hepatitis infection rates are low. This trend may be the result of increases in 'unhealthy lifestyle' factors. The main aim of this study is to identify metabolic signatures associated with healthy lifestyle behaviours and to relate these signatures to risk of developing HCC to investigate whether the metabolites were of predictive utility for HCC beyond data procured from questionnaires. To address this question, we exploited data from a large European cohort (EPIC) which includes detailed questionnaire-based data as well as metabolomic data.

Conditions

• Hepatocellular Carcinoma

Sponsors & Collaborators

• Imperial College London

  collaborator OTHER

• Danish Cancer Society

  collaborator OTHER

• University of Aarhus

  collaborator OTHER

• Centre for Research in Epidemiology and Population Health (CESP)

  collaborator OTHER

• Gustave Roussy, Cancer Campus, Grand Paris

  collaborator OTHER

• German Cancer Research Center

  collaborator OTHER

• German Institute of Human Nutrition

  collaborator OTHER

• Hellenic Health Foundation

  collaborator OTHER

• Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

  collaborator OTHER

• ISPO Cancer Prevention and Research Institute

  collaborator UNKNOWN

• Federico II University

  collaborator OTHER

• HuGeF Foundation

  collaborator UNKNOWN

• Azienda Sanitaria Provinciale Ragusa

  collaborator OTHER

• University of Tromso

  collaborator OTHER

• Institut Català d'Oncologia

  collaborator OTHER

• Ministry of Health - Government of the Principality of Asturias

  collaborator OTHER_GOV

• Andalusian School of Public Health

  collaborator OTHER_GOV

• Universidad de Murcia

  collaborator OTHER

• Instituto de Salud Pública Gobierno de Navarra

  collaborator UNKNOWN

• Subdirección de Salud Pública de Gipuzkoa

  collaborator UNKNOWN

• Skane University Hospital

  collaborator OTHER

• Umeå University

  collaborator OTHER

• MORGEN-EPIC, Bilthoven

  collaborator UNKNOWN

• Prospect-EPIC, Utrecht

  collaborator UNKNOWN

• University of Oxford

  collaborator OTHER

• University of Cambridge

  collaborator OTHER

• International Agency for Research on Cancer

  lead OTHER

Eligibility

Min Age

30 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-08-01

Primary Completion

2017-09-15

Completion

2017-09-15