Prospective Cohort of Patients With Hepatocellular Carcinoma in France

Summary

Hepatocellular carcinoma (HCC) occurs in 90% of cirrhosis primary liver cancers. In France, 8,500 new cases of HCC occur each year, and about 8,000 deaths per year are related to this cancer. The 5-year survival rate is 10%, one of the lowest survival rates of all cancer types. HCC raises a number of major challenges: HCC is discovered at a curable stage in only 25% of cases, reflecting the marked delay in the diagnosis of early stages. The state of knowledge about HCC is well behind that of other cancers (no biomarker, complex carcinogenesis, influence of the aetiology, poorly valorised data, etc.). Rapid technological progress requires large-scale studies to evaluate new diagnostic and therapeutic modalities.

The CHIEF project constitutes a common basis knowledge for research project using prospectively collected data in patients with HCC, regardless of the cause and stage of the cancer.

This project is a Multicentre longitudinal observational study of patients with HCC with prospective data collection on inclusion and patient follow-up. Constitution of a biological resources collection. 5,000 patients will be included over 2 years with a follow-up of patients of 5 years.

Conditions

• Cancer of Liver
• Hepatocellular Carcinoma

Sponsors & Collaborators

• Biobanque de Picardie

  collaborator UNKNOWN

• Société Nationale Française de Gastroentérologie

  collaborator OTHER

• Association Française pour l'Etude du Foie (AFEF)

  collaborator UNKNOWN

• Federation Francophone de Cancerologie Digestive

  collaborator OTHER

• Association Nationale des Hépato-Gastroentérologues des Hôpitaux Généraux (ANGH)

  collaborator UNKNOWN

• UNICANCER

  collaborator OTHER

• Groupe Coopérateur multidisciplinaire en Oncologie (GERCOR)

  collaborator UNKNOWN

• Club de Réflexion des Cabinets et Groupes d'Hépato-Gastroentérologie (CREGG)

  collaborator UNKNOWN

• Association de Chirurgie Hépato-Bilio-Pancréatique et de Transplantation (ACHBT)

  collaborator UNKNOWN

• Société Française de Pathologie (SFP)

  collaborator UNKNOWN

• Société Française de Radiologie (SFR)

  collaborator UNKNOWN

• Societe Francaise de Radiotherapie Oncologique

  collaborator OTHER

• Centre Hospitalier Universitaire, Amiens

  lead OTHER

Principal Investigators

• Jean-Claude BARBARE, Pr · CHU Amiens

• Yves-Edouard HERPE · CHU Amiens

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-09-26

Primary Completion

2027-09-30

Completion

2027-12-31

Countries

• France

Study Locations