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Antibiotic Prophylaxis in Primary Joint Arthroplasty of the Hip and Knee.

NCT03348254 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 242179

Last updated 2019-03-27

No results posted yet for this study

Summary

A retrospective study will be performed to compare the incidence of revision procedures performed for the treatment of postoperative periprosthetic joint infection (PJI) between patients treated with a single preoperative antibiotic prophylaxis and patients treated with multiple shot antibiotic prophylaxis following primary arthroplasty of hip or knee.

This study will be conducted in two phases. In phase 1 the investigators will evaluate which antibiotic prophylaxes (type of antibiotic and duration of prophylaxis) are regularly used in the Netherlands, by contacting all orthopaedic centres implanting total hip and total knee prostheses. In phase 2 the investigators will compare infection rate (defined as revision for infection as registered in the LROI database) between a single-shot and multiple shot antibiotic prophylaxis.

Knee and hip primary arthroplasties will be considered separately.

Conditions

  • Arthroplasty, Replacement, Hip
  • Arthroplasty, Replacement, Knee
  • Antibiotic Prophylaxis

Interventions

DRUG

Single shot antibiotic prophylaxis

single shot preoperative antibiotic prophylaxis

DRUG

Multiple shot antibiotic prophylaxis

Multiple shot perioperative antibiotic prophylaxis

Sponsors & Collaborators

  • Onze Lieve Vrouwe Gasthuis

    lead OTHER

Principal Investigators

  • Rudolf W Poolman, MD PhD · OLVG

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-04-30
Primary Completion
2019-01-31
Completion
2019-03-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03348254 on ClinicalTrials.gov