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Effect of tDCS on Brain Organization and Motor Recovery

NCT03342534 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2025-06-11

No results posted yet for this study

Summary

Neurological deficits and motor disorders are extremely common after stroke. Physical therapies can improve the autonomy of these patients, but despite an intensive stationary neurorehabilitation, severe deficits often persist. Complementary therapies that could improve recovery would therefore be very welcome.

Transcranial direct current stimulation (tDCS) induces, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of certain cerebral regions. An increasing number of studies show that this modulation of brain activity can improve motor functions in patients with brain lesions and increase the effect of physical therapies. However, the "optimum" configuration of tDCS and the induced effects remain to be characterized and investigated.

The investigators therefore propose to carry out a study including a pilot phase in order to determine the most efficient tDCS setup. The optimum setup of of the pilot phase will be compared to a placebo condition in a multicentric main study.

Conditions

Interventions

DEVICE

DC-stimulator (Neuroconn, Germany)

A current of 2 mA will be applied for 20 minutes, 3 times per week during 2 weeks, except for the sham tDCS arm.

Sponsors & Collaborators

  • University Hospital, Geneva

    collaborator OTHER

  • Clinique Romande de Readaptation

    collaborator NETWORK

  • Ecole Polytechnique Fédérale de Lausanne

    collaborator OTHER

  • Adrian Guggisberg

    lead OTHER

Principal Investigators

  • Adrian G Guggisberg, MD · University of Geneva

  • José Millán, PhD · University of Texas - Austin

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-11-13
Primary Completion
2024-04-30
Completion
2024-09-30

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03342534 on ClinicalTrials.gov