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PRecISion Medicine for Children With Cancer

NCT03336931 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 550

Last updated 2024-04-23

No results posted yet for this study

Summary

This is a multicentre prospective study of the feasibility and clinical value of a diagnostic service for identifying therapeutic targets and recommending personalised treatment for children and adolescents with high-risk cancer.

Conditions

  • Childhood Cancer
  • Childhood Solid Tumor
  • Childhood Brain Tumor
  • Childhood Leukemia
  • Refractory Cancer
  • Relapsed Cancer

Interventions

DIAGNOSTIC_TEST

Molecular profiling and drug testing

1. Laboratory analysis including: A. Tumour molecular profiling: targeted whole exon variant analysis, whole genome (DNA) and transcriptome (RNA) sequencing, methylation analysis, proteomics analysis, immunohistochemistry B. In vitro high-throughput drug sensitivity testing C. In vivo drug testing using patient-derived xenograft (PDX) models D. Liquid biopsies 2. Multi-disciplinary Tumour Board case discussion 3. Recommendation of personalised therapy

Sponsors & Collaborators

  • Children's Cancer Institute Australia

    collaborator UNKNOWN

  • Australian & New Zealand Children's Haematology/Oncology Group

    collaborator OTHER

  • Garvan Institute of Medical Research

    collaborator OTHER

  • German Cancer Research Center

    collaborator OTHER

  • Sydney Children's Hospitals Network

    lead OTHER

Principal Investigators

  • A/Prof David Ziegler, MBBS · Sydney Children's Hospitals Network

Eligibility

Max Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-05
Primary Completion
2028-08-31
Completion
2032-12-31

Countries

  • Australia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03336931 on ClinicalTrials.gov