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Epidural Anesthesia and Long-term Outcomes in Elderly Patients After Surgery

NCT03335826 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1802

Last updated 2020-04-14

No results posted yet for this study

Summary

Surgical resection is one of the most important treatments for solid organ cancer. Whereas cancer recurrence and/or metastasis are the major reasons of treatment failure. The outcomes after surgery are mainly dependent on the balance between the immune function of the body and the invasiveness of residual cancer. Preclinical and retrospective studies suggest that anaesthetic techniques and drugs may affect the long-term outcomes in patients undergoing cancer surgery. The investigators hypothesize that epidural anesthesia-analgesia may improve long-term survival in the elderly who undergo major surgery for cancer.

Conditions

  • Elderly Patients
  • Solid Organ Cancer
  • Surgical Resection
  • Epidural Anesthesia
  • Long-term Outcome

Interventions

PROCEDURE

Combined epidural-general anesthesia

Combined epidural-general anesthesia and postoperative epidural analgesia.

PROCEDURE

General anesthesia

General anesthesia and postoperative intravenous analgesia.

Sponsors & Collaborators

  • Peking University People's Hospital

    collaborator OTHER

  • Peking University Third Hospital

    collaborator OTHER

  • Beijing Hospital

    collaborator OTHER_GOV

  • Beijing Shijitan Hospital, Capital Medical University

    collaborator OTHER

  • Peking University First Hospital

    lead OTHER

Principal Investigators

  • Dong-Xin Wang, MD, PHD · Peking University First Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-08-01
Primary Completion
2019-09-30
Completion
2019-09-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03335826 on ClinicalTrials.gov