MedTrace Logo

Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis

NCT03321487 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 4

Last updated 2026-03-20

No results posted yet for this study

Summary

The purpose of this study is to evaluate the safety, tolerability, and feasibility of Blood-Brain Barrier (BBB) opening using transcranial MRI-guided focused ultrasound in conjunction with an intravenous ultrasound contrast agent in patients with Amyotrophic Lateral Sclerosis (ALS).

Conditions

Interventions

DEVICE

Blood-Brain Barrier opening with MRgFUS

ExAblate Transcranial MR-guided Focused Ultrasound to temporarily open the Blood-Brain Barrier

Sponsors & Collaborators

  • InSightec

    lead INDUSTRY

Principal Investigators

  • Lorne Zinman, MD · Medical Director, ALS/Neuromuscular Clinic, Sunnybrook Health Sciences Centre

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-04-13
Primary Completion
2021-12-30
Completion
2023-09-11

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03321487 on ClinicalTrials.gov