Tong-Luo-Qu-Tong Plaster for KOA: a Randomised, Double-blind, Parallel Positive Control, Multi-center Clinical Trial

Summary

Knee osteoarthritis(OA), also known as degenerative arthritis, have affected a lot of people. Patients with severe osteoarthritis frequently develop one or more of the typically following symptoms: joint pain, stiffness, activity with joint friction noise, limited mobility, such as difficulty walking and climbing. Now there are many western medicine treatments including symptom relief and joint cartilage protective agents for OA, but the results have not yet satisfied. TCM treatment of osteoarthritis has remarkable curative effect and unique advantage.Tong-Luo-Qu-Tong Plaster is a common method to treat osteoarthritis of the knee for thousands of years in China. It lacked a large sample randomised, double-blind, parallel positive controlled, multicenter clinical trial, and the clinical evidence of Tong-Luo-Qu-Tong Plaster for Knee Osteoarthritis need to be further completed.

Conditions

• Knee Osteoarthritis
• Chronic Musculoskeletal Disease

Interventions

DRUG

Tong-Luo-Qu-Tong Plaster

for 14 days as two period of treatment, daily 1 time.

DRUG

Qi-Zheng-Xiao-Tong Plaster

for 14 days as two period of treatment, daily 1 time

Sponsors & Collaborators

• Shanghai Zhongshan Hospital

  collaborator OTHER

• Suzhou Hospital of Traditional Chinese Medicine

  collaborator OTHER

• Luoyang Osteopathy hospital of Henan

  collaborator UNKNOWN

• Hubei Hospital of Traditional Chinese Medicine

  collaborator OTHER

• Liaoning University of Traditional Chinese Medicine

  collaborator OTHER

• The Second Hospital of Nanjing Medical University

  collaborator OTHER

• The Fourth Central Hospital of Tianjin

  collaborator UNKNOWN

• Shanghai University of Traditional Chinese Medicine

  lead OTHER

Principal Investigators

• Yongjun Wang, Doctor · Longhua Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-09-12

Primary Completion

2019-12-20

Completion

2020-09-20

Countries

• China

Study Locations