The Influence of Cholecystectomy on Secretion of Incretin Hormones
NCT03305783 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40
Last updated 2023-02-09
Summary
The effect of cholecystectomy on postprandial plasma GLP-1 responses (primary endpoint) and glucose metabolism will be evaluated in 30 patients planned to undergo elective laparoscopic cholecystectomy.
Conditions
- Glucose Metabolism Disorders
Interventions
- PROCEDURE
-
cholecystectomy
elective cholecystectomy performed due to gallstones, cholecystitis or other non-malignant conditions and therefore done regardless of the protocol of this study.
Sponsors & Collaborators
-
University Hospital, Gentofte, Copenhagen
lead OTHER
Principal Investigators
-
Filip K Knop, MD. Proff. · Center for Clinical Metabolic Research, Gentofte hospital
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2017-11-01
- Primary Completion
- 2022-03-11
- Completion
- 2022-04-01
Countries
- Denmark
Study Locations
More Related Trials
-
The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion
NCT01656057 ·Status: COMPLETED ·Phase: NA
-
Effect of Glucagon-like Peptide 2 on Gallbladder Motility After a Meal in Young, Healthy Male Subjects
NCT03682172 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Effect of Bile Acids on GLP-1 Secretion
NCT01666223 ·Status: COMPLETED ·Phase: NA
-
The Effect of Exogenous Glucagon-like Peptide 2 on Cholecystokinin-induced Gallbladder Emptying
NCT04651868 ·Status: COMPLETED ·Phase: NA
-
The Effect of Insulin-induced Hypoglycaemia on Gut-derived Glucagon Secretion (Px-Hypo)
NCT04064203 ·Status: COMPLETED ·Phase: NA
-
A Glucometabolic Evaluation of Patients With Idiopathic Ketotic Hypoglycemia
NCT05310292 ·Status: UNKNOWN ·Phase: NA
-
The Effect of GLP-1 on the Inhibition of Glucagon Secretion
NCT01507597 ·Status: COMPLETED ·Phase: NA
-
The Role of Metformin and Colesevelam in Human GLP-1 Secretion
NCT02050074 ·Status: COMPLETED ·Phase: PHASE4
-
The Anatomical Location, Cellular Origin and Molecular Basis of Gut-derived Glucagon Secretion
NCT03181191 ·Status: COMPLETED ·Phase: NA
-
Effect of GLP-1 and GIP on Insulin Secretion in Type-1 Diabetes Mellitus
NCT00603031 ·Status: COMPLETED ·Phase: NA
-
Involvement of Steatosis-induced Glucagon Resistance in Hyperglucagonaemia
NCT02337660 ·Status: COMPLETED ·Phase: NA
-
Glucagon Resistance in Patients With NAFLD
NCT04042142 ·Status: COMPLETED ·Phase: NA
-
Influence of Glucagon Inhibition in Relation to the Anti-Diabetic Effect of Glucagon-Like Peptide-1 (GLP-1) in Patients With Type 2 Diabetes Mellitus
NCT00655603 ·Status: UNKNOWN ·Phase: NA
-
Insulin Sensitivity and Metabolomics During Oral Administration of Glucose and Graded Intravenous Infusion
NCT03223129 ·Status: COMPLETED ·Phase: NA
-
Effect of RYGB on Alpha- and Beta Cell Function and Sensitivity to Incretins in Patients With Type 2 Diabetes
NCT04782999 ·Status: COMPLETED ·Phase: NA
-
Separate and Combined Extrapancreatic Effects of GIP and GLP-1
NCT06895408 ·Status: COMPLETED ·Phase: NA
-
Effect of Bile Acid Sequestration on Postprandial GLP-1 Secretion, Glucose Homeostasis and Gut Microbiota
NCT02061124 ·Status: COMPLETED ·Phase: NA
-
Endogenous Glucoseproduction in Patients With Type 2 Diabetes Mellitus During Oral Glucose and iv. Glucose Infusion
NCT02010827 ·Status: COMPLETED
-
Incretin Hormones in Type-1 Diabetes Mellitus Glycemic Response in Type-1 Diabetes Mellitus
NCT00832741 ·Status: COMPLETED
-
The Role of Small Intestinal Endocrine Cells in Type 2 Diabetic Hyperglucagonemia
NCT00639613 ·Status: COMPLETED
-
Effect of Bile Acid Secretion and Sequestration on GLP-1 Secretion
NCT02445508 ·Status: COMPLETED ·Phase: NA
-
The Effect of Gastric Bypass Surgery on the Glucose Metabolism Seen in Patients With Type 2 Diabetes
NCT00810823 ·Status: COMPLETED
-
The Importance of Ghrelin for Glucose Metabolism After Sleeve Gastrectomy
NCT05189353 ·Status: COMPLETED ·Phase: NA
-
Hyperglycemia and the Extra-pancreatic Effect of Incretins
NCT01749163 ·Status: COMPLETED ·Phase: NA
-
Physiology of GIP(1-30)NH2 in Humans
NCT04792762 ·Status: COMPLETED ·Phase: NA