MR Assessment of Hepatic Hydatid Disease

Summary

Hydatid disease is a major healthcare problem worldwide caused by infection that commonly affects the liver. Treatments for hydatid disease depend on how advanced the disease is and if the infection is active or not. Currently, doctors decide what stage the disease is at by looking at the appearance of liver on scans and by performing blood tests. It is however still very difficult to be certain if a treatment is working and when is the right moment to start and stop medication. Magnetic Resonance Imaging (MRI) scanning is a safe and non-invasive way of imaging the liver that can provide detailed information not just about what the liver looks like but also other information about the chemical composition of normal and diseased liver tissue. MRI is already widely used in the NHS for many liver conditions but it is unknown whether analysing the chemical composition will help decide on the stage and activity of hydatid liver disease. This study will allow comparison between MRI information about liver structure and composition with existing methods of assessing disease stage. If fluid is later obtained from the liver as part of usual clinical care (either using a needle with ultrasound or at the time of surgery), this study will also compare information about the fluid composition obtained from MRI scanning, with the results obtained when analysing the fluid in the lab. This will help to develop a more accurate way of non-invasively assessing hydatid disease in the liver, in the future.

Conditions

• Cystic Echincoccosis
• Hydatid Disease

Interventions

OTHER

MRI scan (not involving ionising radiation)

The MRI study will be conducted by a trained MR radiographer, supervised by the nominated researcher

OTHER

Ultrasound scan (not involving ionising radiation)

The US scan will be conducted by a nominated researcher

OTHER

Ex vivo MRI scan of cyst fluid sample

The MRI study will be conducted by a trained MR radiographer, supervised by the nominated researcher

OTHER

Aspiration of cyst fluid

For patients undergoing surgery/radiologically guided aspiration the aspiration will be performed by a surgeon (at the Royal Free Hospital) or radiologist

OTHER

Blood test for confirmation of serum IgG levels consistent with hydatid infection

The blood sample will be drawn by a member of the clinical team

Sponsors & Collaborators

• University College, London

  lead OTHER

Eligibility

Min Age

16 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-08-14

Primary Completion

2020-03-01

Completion

2020-03-01

Countries

• United Kingdom

Study Locations