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Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level

NCT03288610 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2017-09-25

No results posted yet for this study

Summary

The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications. The investigators hypothesize that an increase of the preoperative stimulation of vasopressinergic system (in response to acute or chronic conditions) could lead to a microcirculatory dysfunction and favor the occurrence of vasodilatation during and after CPB and increase the symptoms of an inflammatory response after CPB. By defining a high risk population, a targeted strategy of monitoring and early or preventive treatment could improve postoperative prognosis.

Conditions

  • Systemic Inflammatory Response Syndrome (SIRS)
  • Postoperative Vasodilation Syndrome
  • Stress Response
  • Cardiac Surgery Prognosis
  • Tissue Oxygenation and Post-ischemic Response

Interventions

DIAGNOSTIC_TEST

Preoperative copeptin level

Measure of plasmatic copeptin from preoperative samples retained in a biorepository. Physicians are blinded to the result.

Sponsors & Collaborators

  • Thermo Fisher Scientific, Inc

    collaborator INDUSTRY

  • University Hospital, Montpellier

    lead OTHER

Principal Investigators

  • Philippe Gaudard, MD · Montpellier University Hospital

Eligibility

Min Age
18 Years
Max Age
81 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-31
Primary Completion
2017-07-31
Completion
2017-08-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03288610 on ClinicalTrials.gov