Intensity-Modulated Stereotactic Radiation Therapy in Treating Patients With Grade II-IV Glioma
NCT03251027 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100
Last updated 2026-01-27
Summary
This phase II trial studies how well intensity-modulated stereotactic radiation therapy works in treating patients with grade II-IV glioma. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue.
Conditions
- Glioblastoma
- WHO Grade II Glioma
- WHO Grade III Glioma
Interventions
- OTHER
-
Quality-of-Life
Ancillary studies
- RADIATION
-
Intensity-Modulated Radiation Therapy
Undergo IM-SRT
Sponsors & Collaborators
-
Sidney Kimmel Cancer Center at Thomas Jefferson University
lead OTHER
Principal Investigators
-
Wenyin Shi, MD · Thomas Jefferson University
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-07-17
- Primary Completion
- 2027-12-31
- Completion
- 2027-12-31
Countries
- United States
Study Locations
More Related Trials
-
Adjuvant Hypofractionated Stereotactic Radiosurgery for Intermediate-risk Meningioma
NCT06557512 ·Status: RECRUITING ·Phase: NA
-
Temozolomide and Radiation Therapy in Treating Patients With Gliomas
NCT00114140 ·Status: COMPLETED ·Phase: PHASE2
-
Temozolomide, Radiation Therapy, and Tumor Treating Fields Therapy in Treating Participants With Glioblastoma
NCT03477110 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
High-Dose Vorinostat and Fractionated Stereotactic Body Radiation Therapy in Treating Patients With Recurrent Glioma
NCT01378481 ·Status: TERMINATED ·Phase: PHASE1
-
Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases
NCT01644591 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Personalized Radiation Therapy for GBM
NCT03477513 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma
NCT00978458 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma
NCT03180502 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Hypofractionated Stereotactic Radiotherapy in Recurrent Glioblastoma Multiforme
NCT01464177 ·Status: COMPLETED ·Phase: PHASE2
-
Phase 1-2 of Temozolomide and Hypofractionated Radiotherapy in Tx of Supratentorial Glioblastoma Multiform
NCT01120639 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Anaplastic Astrocytoma
NCT00841555 ·Status: COMPLETED ·Phase: PHASE1
-
Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma
NCT01392209 ·Status: COMPLETED ·Phase: PHASE1
-
Temozolomide and Radiation Therapy With or Without Cediranib Maleate in Treating Patients With Newly Diagnosed Glioblastoma
NCT01062425 ·Status: COMPLETED ·Phase: PHASE2
-
Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery
NCT01372774 ·Status: COMPLETED ·Phase: PHASE3
-
Stereotactic Radiation Therapy in Treating Patients With Brain Metastases
NCT00006259 ·Status: COMPLETED ·Phase: PHASE2
-
Temozolomide Plus Radiation Therapy in Treating Patients With Newly Diagnosed Anaplastic Oligodendrogliomas or Mixed Anaplastic Oligoastrocytomas
NCT00033280 ·Status: COMPLETED ·Phase: PHASE2
-
Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
NCT00305864 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
NCT06344130 ·Status: RECRUITING ·Phase: PHASE1
-
Treatment of High-grade Gliomas Using Hypofractionated Radiation Therapy -a Phase I Clinical Trial
NCT03082846 ·Status: COMPLETED ·Phase: NA
-
Studying the Safety, Efficacy, and Pharmacokinetic Characteristics of BNCT in Patients With Recurrent High-grade Gliomas
NCT05737212 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma
NCT00058370 ·Status: COMPLETED ·Phase: NA
-
Stereotactic Radiosurgery in Treating Patients With Brain Metastases
NCT00811655 ·Status: TERMINATED ·Phase: PHASE2
-
A Study Evaluating the Association of Hypofractionated Stereotactic Radiation Therapy and Durvalumab for Patients With Recurrent Glioblastoma
NCT02866747 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Low Dose Radiation Therapy for Glioblastoma Multiforme
NCT01466686 ·Status: COMPLETED ·Phase: PHASE2
-
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
NCT02709226 ·Status: COMPLETED ·Phase: PHASE1