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Long-Term Survival After Ischaemic Stroke: Ebrictus Study

NCT03247036 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 21000

Last updated 2022-04-11

No results posted yet for this study

Summary

A number of large trials have confirmed the benefits of thrombolysis in acute stroke, but there are gender differences. The authors sought to examine the relationship between sex and outcome after thrombolysis.

Previous reports \[1-6\] concerning sex-related differences in stroke management and outcome are inconsistent and sometimes difficult to interpret, and so the reasons for gender disparities in stroke outcome have remained unclear. Functional outcomes and quality of life after stroke are consistently poorer in women despite adjustment for baseline differences in age and prestroke function, and the fact that comorbidities and clinical outcomes were not different between women and men \[3, 7\] . Once the reasons for these differences are better understood, intervention might be possible to help provide the best care for all patients. This work is a continuation and extension of the Ebrictus Study \[8-10\] . Prior work has suggested sex-based differences in thrombolytic therapy in subjects with acute stroke \[11\] .The authors will explore whether sex might modify the effect of thrombolysis on survival and functional outcomes in patients with acute ischemic stroke \[12\] beyond the usually evaluated time period of 6 months after stroke and compared this with the group without thrombolytic treatment.

Conditions

  • Ischemic Stroke
  • Thrombolytic (t-PA) Treatment
  • Gender Bias
  • Long Term Adverse Effects

Interventions

DRUG

IV thrombolytic (t-PA) treatment vs not

Acute Stroke Protocol

Sponsors & Collaborators

  • Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina

    lead OTHER

Eligibility

Min Age
15 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-13
Primary Completion
2017-07-30
Completion
2017-08-05

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03247036 on ClinicalTrials.gov