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Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers

NCT03232138 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 43

Last updated 2024-12-17

Study results available
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Summary

This research study involves taking an experimental anti-cancer dietary supplement called Sulforaphane (SF) or a placebo (product without any supplement content) over a period of twelve months in order to determine if it is a useful dietary supplement for prevention of lung cancer in humans.

The main goals of this research study are:

1. To learn about the effects of giving Sulforaphane (SF) to former smokers who are still at high risk of developing cancer due to their smoking history and whether or not their condition improves, stays the same or becomes worse after Sulforaphane (SF) is given.
2. To learn whether Sulforaphane (SF) might reverse some of the lung cell changes associated with future development of lung cancer.

Conditions

Interventions

DIETARY_SUPPLEMENT

Sulforaphane

Sulforaphane (SF) is a naturally occurring substance (phytochemical) found in cruciferous vegetables.

DRUG

Placebo

Inactive ingredients

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Jian-Min Yuan, MD

    lead OTHER

Principal Investigators

  • Jian-Min Yuan, MD, PhD · Univesity of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
55 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-25
Primary Completion
2023-02-17
Completion
2023-02-17
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03232138 on ClinicalTrials.gov