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Role of Monocytes Adhesion and Vascular Lesions in Vascular Access Success or Failure in Uremic Patients

NCT03231410 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2018-05-22

No results posted yet for this study

Summary

This study is designed to identify novel predictors of vascular access success or failure in chronic kidney disease patients. Despite efforts to improve placement of arteriovenous fistula (AVF) the primary failure rates are reported as high as 20-50%, but standard tools like ultrasound cannot inform the clinician sufficiently to accurately predict success or failure.

The aim of this study is to perform enhanced assessments of arterial health preoperatively and correlate these measurements with vascular lesions (microscopic tissue changes and monocyte infiltration) and early AVF outcome.

Activation of monocytes in uremia condition is responsible for endothelium dysfunction, intimal hyperplasia and atherosclerosis. The investigators expect that stiff arteries caused by monocyte dysfunction refer to the poor distensability and probably longer maturation time.

Conditions

Sponsors & Collaborators

  • Universitätsklinikum Halle

    collaborator UNKNOWN

  • Wroclaw Medical University

    lead OTHER

Principal Investigators

  • Tomasz Gołębiowski, MD, PhD · Department of Nephrology and Transplantation Medicine, Wroclaw Medical University

  • Mariusz Kusztal, MD, PhD · Department of Nephrology and Transplantation Medicine, Wroclaw Medical University

  • Krzysztof Letachowicz, MD, PhD · Department of Nephrology and Transplantation Medicine, Wroclaw Medical University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-31
Primary Completion
2019-06-30
Completion
2019-08-31

Countries

  • Poland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03231410 on ClinicalTrials.gov