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DHEA Augmentation of Musculoskeletal Adaptations to Exercise in Older Women

NCT03227458 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 152

Last updated 2024-12-05

No results posted yet for this study

Summary

To determine whether the musculoskeletal adaptations to bone-loading exercise can be significantly augmented in older women (aged 60-85) with low bone mass (osteopenia; T-scores \<-1.0 and \>-2.5) or moderate osteoporosis (T-scores \< -2.5 and \>= -3.0) and by restoring serum DHEAS to young adult levels by oral DHEA replacement.

Conditions

  • Low Bone Mass
  • Osteoporosis, Postmenopausal

Interventions

OTHER

DHEA

Participants will take 1 study pill (50 mg DHEA) daily for 36 weeks.

OTHER

Placebo

Participants will take placebo daily for 36 weeks.

BEHAVIORAL

Exercise

bone-loading exercise on 3 days per week for 38 weeks

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • University of Colorado, Denver

    lead OTHER

Principal Investigators

  • Catherine Jankowski, PhD · University of Colorado, Denver

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
55 Years
Max Age
85 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-12
Primary Completion
2024-06-19
Completion
2024-06-19

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03227458 on ClinicalTrials.gov