Driving Reduced AIDS-associated Meningo-encephalitis Mortality

Summary

The DREAMM project is investigating whether the DREAMM interventions (1) Health system strengthening, 2) Co-designed education programs tailored to frontline healthcare workers, 3) Implementation of a diagnostic and treatment algorithm and, 4) Communities of practice in infectious diseases and laboratory capacity building) when combined reduce two week all-cause mortality of HIV-associated meningo-encephalitis in African LMICs.

Conditions

• AIDS-Related Opportunistic Infections
• Meningo-encephalitis
• Cryptococcal Meningitis
• Bacterial Meningitis
• Tuberculous Meningitis
• Cerebral Toxoplasmosis

Interventions

OTHER

DREAMM

4 DREAMM interventions to reduce HIV-related meningoencephalitis mortality once access to essential diagnostic tests and medicines: 1. Health system strengthening 2. Delivery of a co-designed education program tailored to frontline healthcare workers 3. Implementation of an algorithm for HIV-related meningoencephalitis 4. Infectious diseases/AHD mentorship and laboratory capacity building

Sponsors & Collaborators

• European and Developing Countries Clinical Trials Partnership (EDCTP)

  collaborator OTHER_GOV

• National Agency for Research on AIDS and Viral Hepatitis (ANRS)

  collaborator OTHER

• Institut Pasteur

  collaborator INDUSTRY

• National Institute for Medical Research, Tanzania

  collaborator OTHER_GOV

• Amana Hospital, Dar es Salaam, Tanzania

  collaborator UNKNOWN

• University of North Carolina Project-Malawi (UNC Project), Lilongwe, Malawi

  collaborator UNKNOWN

• Kamuzu Central Hospital

  collaborator OTHER

• Yaounde Central Hospital

  collaborator OTHER_GOV

• Zomba Central Hospital, Zomba, Malawi

  collaborator UNKNOWN

• Lighthouse Trust

  collaborator OTHER

• Mwananyamala Hospital, Dar es Salaam, Tanzania

  collaborator UNKNOWN

• St George's, University of London

  lead OTHER

Principal Investigators

• Angela Loyse, MD · St George's, University of London

Study Design

Allocation

NA

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

SEQUENTIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-04-23

Primary Completion

2021-04-30

Completion

2021-09-30

Countries

• Cameroon
• Malawi
• Tanzania

Study Locations