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Home Assessment and Initiation of Antiretroviral Therapy for HIV in Malawi

NCT01414413 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16660

Last updated 2014-04-07

Study results available
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Summary

Despite increasing availability of antiretroviral therapy (ART) for HIV in high prevalence countries, the majority of people with HIV infection still initiate treatment at an advanced stage of disease. This leads to a high risk of death soon after HIV diagnosis. Prompt HIV diagnosis is, therefore, necessary for both individual and public health benefit and is being strongly promoted as international and national policy in Malawi. However timely HIV diagnosis may not in itself be sufficient to ensure ART initiation: this is reflected by the relatively high proportion of individuals who defer treatment-seeking for months or years following diagnosis of HIV.

Here the researchers investigate the extent to which home assessment and initiation of ART adds to the effectiveness of a home-based HIV testing and counseling strategy, using entry to, adherence with, and retention in HIV care as the outcome of interest.

Conditions

Interventions

OTHER

Home assessment and initiation of ART

Home-based ART eligibility assessment (WHO staging, CD4 count measurement and educational treatment preparation) and initiation.

OTHER

Clinic-based ART assessment and initiation

Participants who meet eligibility criteria and reside in a cluster that has been allocated to the control arm of this study will receive supported access to ART care through the primary care system for confirmation of HIV status and entry into HIV following disclosure to the resident community counsellor.

Sponsors & Collaborators

  • Kamuzu University of Health Sciences

    collaborator OTHER

  • London School of Hygiene and Tropical Medicine

    collaborator OTHER

  • Ministry of Health and Population, Malawi

    collaborator OTHER_GOV

  • Liverpool School of Tropical Medicine

    lead OTHER

Principal Investigators

  • Peter MacPherson, MBChCB MPH · Liverpool School of Tropical Medicine

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2012-11-30
Completion
2013-04-30

Countries

  • Malawi

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01414413 on ClinicalTrials.gov