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Changes in PPV Induced by PLR Test to Predict Fluid Responsiveness in ICU

NCT03225378 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 286

Last updated 2021-10-27

No results posted yet for this study

Summary

The passive leg raising (PLR) test is a reversible preload challenge of around 300 mL of blood that can be repeated as frequently as required without infusing a drop of fluid. Two recent meta-analyses of many studies have confirmed the reliability of the PLR test to predict fluid responsiveness in patients with acute circulatory failure. Nevertheless, the effects of the PLR must be assessed by the direct measurement of cardiac output since changes in arterial pressure do not allow the assessment of the PLR hemodynamic effects with reliability. Moreover, cardiac output must be measured continuously and in real time.

In clinical practice, cardiac output measurement can be difficult for different reasons such as the unavailability of the echocardiography machine, or the absence of any continuous cardiac output monitoring technique at the time of acute circulatory failure occurrence.

Recently, it was shown that the decrease in pulse pressure variation (PPV) induced by the mini-fluid challenge (100 mL of colloid solution infused in 1 min) was able to predict fluid responsiveness with reliability in patients ventilated with low tidal volume (\<8 mL/kg of ideal body weight).

Therefore, the investigators hypothesize that the changes in PPV induced by PLR test could be able to predict fluid responsiveness with reliability in mechanically ventilated patients with acute circulatory failure.

Conditions

  • Acute Circulatory Failure

Interventions

OTHER

Fluid loading of 500 mL of crystalloid solution

Infusion of 500 mL of crystalloid solution in less than 15 minutes

OTHER

Passive Leg Raising test

This intervention is done before the fluid loading in order to predict fluid responsiveness.

Sponsors & Collaborators

  • Centre Hospitalier Arras

    lead OTHER

Principal Investigators

  • Jihad MALLAT, MD · Centre Hospitalier Arras

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-21
Primary Completion
2021-09-20
Completion
2021-09-20

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03225378 on ClinicalTrials.gov