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Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency

NCT02415218 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2019-10-11

No results posted yet for this study

Summary

The study purpose is to evaluate the efficacy and safety of cultivated oral mucosal epithelial sheet transplantation as a novel therapy for limbal stem cell deficiency, for which no effective approaches has thus far been available, for the purpose of establishing this therapy as an effective strategy for this disease with an aim of improving visual acuity and corneal transparency.

Conditions

  • Limbal Stem-cell Deficiency

Interventions

BIOLOGICAL

Mucosal cell sheet transplantation

The subjects will have their oral mucosal tissues retrieved for cell sheet preparation. The mucosal cell sheet will be transplanted over the affected cornea.

Sponsors & Collaborators

  • Osaka University

    collaborator OTHER

  • Siriraj Hospital

    lead OTHER

Principal Investigators

  • Adisak Wongkajornsilp, M.D., Ph.D. · Mahidol University

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-04-17
Primary Completion
2016-09-03
Completion
2017-04-16

Countries

  • Thailand

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02415218 on ClinicalTrials.gov