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Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery

NCT03214510 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 101

Last updated 2026-03-05

No results posted yet for this study

Summary

This phase III trial studies how well thoracic epidural analgesia or four-quadrant transversus abdominus plane block works in reducing pain in patients undergoing liver surgery. It is not yet known whether thoracic epidural analgesia or four-quadrant transversus abdominus plane block may help people to recover more completely and more quickly after surgery.

Conditions

  • Liver and Intrahepatic Bile Duct Disorder

Interventions

DRUG

Bupivacaine

Given via thoracic epidural catheter or TAP block

DRUG

Fentanyl

Given via thoracic epidural catheter

DRUG

Hydromorphone Hydrochloride

Given via thoracic epidural catheter

DEVICE

Implanted Medical Device

Undergo placement of thoracic epidural catheter

DEVICE

Implanted Medical Device

Undergo placement of ultrasound-guided, four-quadrant transversus abdominus plane block

DRUG

Liposomal Bupivacaine

Given via TAP block

BEHAVIORAL

Questionnaire

Ancillary studies

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • M.D. Anderson Cancer Center

    lead OTHER

Principal Investigators

  • Timothy E. Newhook, MD · M.D. Anderson Cancer Center

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-10-04
Primary Completion
2026-07-31
Completion
2026-07-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03214510 on ClinicalTrials.gov