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Inflammation and Cell Maturation in Preterm Delivery Placentas - in Vitro and in Vivo Effect of Progesterone

NCT03211338 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 115

Last updated 2022-06-23

No results posted yet for this study

Summary

The aim of this study is to investigate the In Vitro and In Vivo effect of progesterone on immature myeloid cells (IMC), inflammation characteristics and maturation into dendritic cells (DC).

Conditions

  • Obstetric Labor, Premature

Interventions

BIOLOGICAL

Culture with progesterone

Progesterone, a steroid hormone will be cultured with placental IMC cells or peripheral blood CD14+ monocyte cells

BIOLOGICAL

Culture without progesterone

Culture of placental IMC cells or peripheral blood CD14+ monocyte cells without progesterone

BIOLOGICAL

Culture with growth factors

Culture of placental IMC cells with growth hormones only and analysis

Sponsors & Collaborators

  • Hillel Yaffe Medical Center

    lead OTHER_GOV

Principal Investigators

  • Rinat Gabbay-Benziv, MD · Hillel Yaffe Medical Center

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-07-15
Primary Completion
2022-06-06
Completion
2022-06-06

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03211338 on ClinicalTrials.gov