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Effect of Preemptive Epidural Analgesia in Labor on Cytokine Production

NCT00361712 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 41

Last updated 2018-04-09

Study results available
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Summary

During labor there is an increased production of inflammatory mediators called cytokines. Higher concentration of certain cytokines has been linked to adverse neonatal and maternal outcomes.

Epidural analgesia is commonly performed after the parturient feels labor pain.

We hypothesis that preemptive epidural analgesia (initiated before labor pain begins)can influence the production of cytokines.

Conditions

  • Obstetric Pain

Interventions

PROCEDURE

Preemptive epidural analgesia

Parturients will receive early epidural analgesia before onset of painful contractions as oppose to standard of care in which parturients receive epidural analgesia with onset of painful contractions.

DRUG

Standard of care

Epidural analgesia with parturients with cervical dilatation and painful labor (VAS \>5)

Sponsors & Collaborators

  • Rabin Medical Center

    lead OTHER

Principal Investigators

  • Sharon Orbach-Zinger, M.D. · Department of Anesthesiology, Rabin Medical Center/Beilinson Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-07-31
Primary Completion
2006-07-31
Completion
2006-07-31

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00361712 on ClinicalTrials.gov