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Quantitative MR Imaging in Locally Advanced Cervical Cancer

NCT03210428 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 320

Last updated 2020-02-17

No results posted yet for this study

Summary

Hypoxic tumour cells within the primary tumour have shown prognostic importance for local and metastatic disease control in several cancer sites. Radioresistant hypoxic cells diminish the rate of local control, and the hypoxia driven increase in metastatic potential of the tumour and lowers the rate of distant disease control. DCE MR imaging has been used to quantify the extent of poor perfusion regions within cervical tumours and it has been shown to be a surrogate of hypoxia. Furthermore, a number of studies have demonstrated that DCE MR is predictive of disease failure in cervix cancer.

The EMBRACE II study will implement an imaging sub-study, which will evaluate the value of quantitative MR imaging to identify patients at increased risk of disease recurrence (local, nodal and systemic).

Conditions

  • Neoplasms
  • Functional Magnetic Resonance Imaging
  • Radiotherapy

Sponsors & Collaborators

  • The Netherlands Cancer Institute

    collaborator OTHER

  • Aarhus University Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-10-18
Primary Completion
2021-09-30
Completion
2023-09-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03210428 on ClinicalTrials.gov