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NK Cell Mediated Influenza Immunity During Pregnancy

NCT03196245 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 94

Last updated 2023-07-14

No results posted yet for this study

Summary

Pregnant women have increased morbidity and mortality due to infection with influenza. Changes in T cell function have been proposed as possible mechanisms for this finding. We believe that pregnancy induced changes in NK cell phenotype and function also impact influenza immunity. This study will compare the immune response of pregnant women and controls to TIV influenza vaccination as a surrogate for infection. In addition pregnant women with flu like illness will be enrolled to evaluate changes in immune response following influenza infection as compared to vaccination.

Conditions

  • Pregnancy Related
  • Influenza, Human

Interventions

OTHER

There is no intervention.

There is no intervention. This is a purely observational study. We enrolled pregnant women as they received a vaccine as part of their regular medical care; we did not administer the vaccine. We also enrolled pregnant women acutely infected with influenza.

Sponsors & Collaborators

  • Doris Duke Charitable Foundation

    collaborator OTHER

  • National Institutes of Health (NIH)

    collaborator NIH

  • Stanford University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-08-14
Primary Completion
2019-04-01
Completion
2019-04-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03196245 on ClinicalTrials.gov