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Downstream Molecular Signals of P2Y12 Receptors in Hyporeactive Patients Under Clopidogrel Treatment A Possible Mechanism of HOTPR(High On-Treatment Platelet Reactivity)

NCT03190005 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2019-11-21

Study results available
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Summary

The investigators designed the following experiment to observe the pattern of administration in vitro, which can be completely excluded liver enzyme cytochrome P450 metabolism under the influence and observe the relevant P2Y12 receptor downstream signal changes, hope in the above experiments, that the human body directly for the difference between the existence of drug reactions exist.

Conditions

  • Stable Angina

Interventions

DRUG

clopidogrel

routine Dual antiplatelet therapy after stent implantation, then check PRU(platelet reactivity unit)

DRUG

Placebos

no medication, healthy subjects.

Sponsors & Collaborators

  • Taipei City Hospital

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-01
Primary Completion
2017-11-01
Completion
2017-11-01

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03190005 on ClinicalTrials.gov