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Natural History of Granulomatosis With Polyangiitis: Clinical and Genetic Biomarkers of Airway Disease NoAAC PR-03 Study

NCT03182049 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2020-08-25

No results posted yet for this study

Summary

The ultimate goal of this prospective natural history study is to define the natural history of the obstructive airway manifestations of Granulomatosis with polyangiitis (GPA).

Additionally this proposal seeks to develop biomarkers of disease activity and define their correlation with clinical outcomes in an effort to transform clinical care and shape future drug development for this devastating rare disease.

Conditions

  • Granulomatosis With Polyangiitis

Interventions

PROCEDURE

Airway assessment

Airway Specialist (Otolaryngology, Pulmonology, Thoracic Surgery), assess clinical location and degree of airway compromise, glottic mobility, and sinonasal disease.

PROCEDURE

Rheumatology assessment

Clinically assess systemic function (renal/pulmonary ect), biochemical profile (routine labs), neurocognitive function, and completing entry BVAS tool.

Sponsors & Collaborators

  • North American Airway Collaborative (NoAAC)

    collaborator UNKNOWN

  • Vasculitis Patient Powered Research Network (VPPRN)

    collaborator UNKNOWN

  • Vasculitis Clinical Research Consortium (VCRC)

    collaborator NETWORK

  • Vanderbilt University Medical Center

    lead OTHER

Principal Investigators

  • Alexander Gelbard, MD · Vanderbilt University Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-31
Primary Completion
2022-05-31
Completion
2023-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03182049 on ClinicalTrials.gov