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Functional Magnetic Resonance Imaging of Human Hypothalamic Responses to Oral Temperature and Glucose Sensing

NCT03181217 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2017-06-09

No results posted yet for this study

Summary

The study will consist of four occasions with one week between the occasions. fMRI will be performed to monitor hypothalamic activity before and after an ingestion of 1 of the following 4 stimuli (300 ml of each): water at room temperature, water at 0 degrees Celsius, glucose solution at room temperature, glucose solution at 0 degrees Celsius. The last two stimuli both contain 75 gram glucose. The order of conditions will be randomly assigned to the subjects. Functional connectivity of the hypothalamic regions will be assessed by analysing the resting state fMRI.

Conditions

  • Healthy

Interventions

OTHER

water 0

300 ml tap water at 0 ºC

OTHER

water 22

300 ml tap water at 22 ºC

OTHER

Glucose 0

300 ml tap water at 0 ºC with 75 grams of glucose added

OTHER

Glucose 22

300 ml tap water at 22 ºC with 75 grams of glucose added

Sponsors & Collaborators

  • Leiden University Medical Center

    collaborator OTHER

  • Unilever R&D

    lead INDUSTRY

Principal Investigators

  • Jeroen van der Grond · Leiden University Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-01-28
Primary Completion
2013-05-23
Completion
2013-05-23

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03181217 on ClinicalTrials.gov