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Handling Oxygenation Targets in the Intensive Care Unit

NCT03174002 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 2928

Last updated 2021-10-26

No results posted yet for this study

Summary

Handling oxygenation targets (HOT) is standard of care in the intensive care unit (ICU), however the quality and quantity of evidence is low and potential harm has been reported. The aim of the HOT-ICU trial is to assess the overall benefits and harms of two levels of oxygenation targets in adult critically ill patients with acute hypoxaemic respiratory failure in the ICU.

Conditions

  • Hypoxemic Respiratory Failure
  • Oxygen Toxicity

Interventions

DRUG

Oxygen

Oxygen administration to achieve a PaO2 of 8 kPa (60 mmHg) from ICU admission to ICU discharge

DRUG

Oxygen

Oxygen administration to achieve a PaO2 of 12 kPa (90 mmHg) from ICU admission to ICU discharge

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    collaborator OTHER

  • Copenhagen Trial Unit, Center for Clinical Intervention Research

    collaborator OTHER

  • Aalborg University Hospital

    lead OTHER

Principal Investigators

  • Bodil Steen Rasmussen, MD, PhD · Aalborg University Hospital, Denmark

  • Anders Perner, MD, PhD · Rigshospitalet, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-06-19
Primary Completion
2020-11-03
Completion
2021-08-03

Countries

  • Denmark
  • Finland
  • Iceland
  • Netherlands
  • Norway
  • Switzerland
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03174002 on ClinicalTrials.gov