MedTrace Logo

Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)

NCT03173456 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2022-02-01

Study results available
· View outcomes & findings →

Summary

This study compares the efficacy of five oral analgesics: 5 mg oxycodone + 325 mg acetaminophen, 5 mg hydrocodone + 300 mg acetaminophen, 30 mg codeine + 300 mg acetaminophen, 400 mg ibuprofen + 1000 mg acetaminophen, and 800 mg ibuprofen + 1000 mg acetaminophen for the treatment of patients with acute musculoskeletal pain who present to the Emergency Department (ED).

Conditions

Interventions

DRUG

oxycodone/APAP

Oxycodone/acetaminophen 5 mg-325 mg oral tablet

DRUG

hydrocodone/APAP

Hydrocodone/Acetaminophen 5 Mg-300 Mg oral tablet

DRUG

codeine/APAP

Codeine/acetaminophen 30 mg-300mg oral tablet

DRUG

400 ibuprofen/APAP

ibuprofen/acetaminophen 400 mg-1000mg oral tablet

DRUG

800 ibuprofen/APAP

ibuprofen/acetaminophen 800 mg-1000 mg oral tablet

Sponsors & Collaborators

  • Albert Einstein College of Medicine

    lead OTHER

Principal Investigators

  • Benjamin Friedman, MD · Albert Einstein College of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-11-28
Primary Completion
2019-11-14
Completion
2019-11-14
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03173456 on ClinicalTrials.gov